lgmn Phenotypes

Phenotypes

XB-GENEPAGE-950604

Gene Symbol: lgmn Gene Name: legumain

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: lgmn assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (31 sources): abnormal adaptive immunity, abnormal body length, abnormal bone marrow cell morphology/development, abnormal kidney interstitium morphology, abnormal kidney outer medulla outer stripe morphology, abnormal macrophage physiology, abnormal prepulse inhibition, abnormal proximal convoluted tubule morphology, abnormal renal glomerulus morphology, accumulation of giant lysosomes in kidney/renal tubule cells, decreased body length, decreased erythrocyte cell number, decreased hematocrit, decreased hemoglobin content, decreased interleukin-12b secretion, decreased interleukin-6 secretion, decreased mean corpuscular hemoglobin, decreased mean corpuscular hemoglobin concentration, decreased prepulse inhibition, decreased renal glomerular filtration rate, decreased tumor necrosis factor secretion, immune system phenotype, increased body temperature, increased circulating creatinine level, increased circulating tumor necrosis factor level, increased liver weight, increased spleen weight, lysosomal protein accumulation, pale kidney, renal glomerulus cyst, slow postnatal weight gain [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (31 sources): abnormal adaptive immunity, abnormal body length, abnormal bone marrow cell morphology/development, abnormal kidney interstitium morphology, abnormal kidney outer medulla outer stripe morphology, abnormal macrophage physiology, abnormal prepulse inhibition, abnormal proximal convoluted tubule morphology, abnormal renal glomerulus morphology, accumulation of giant lysosomes in kidney/renal tubule cells, [+]