| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormal Descemet membrane morphology,
Abnormal anterior chamber morphology,
Abnormality iris morphology,
Abnormality of the optic nerve,
Anterior synechiae of the anterior chamber,
Buphthalmos,
Central opacification of the cornea,
Central scotoma,
Corneal neovascularization,
Corneal opacity,
Developmental glaucoma,
Glaucoma,
Glaucomatous visual field defect,
High myopia,
Increased cup-to-disc ratio,
Late onset congenital glaucoma,
Nevus flammeus,
Nystagmus,
Ocular hypertension,
Opacification of the corneal stroma,
Open angle glaucoma,
Optic neuropathy,
Peripheral visual field loss,
Peters anomaly,
Posterior synechiae of the anterior chamber,
Retinal arterial occlusion,
Retinal detachment,
Retinal vein occlusion,
Strabismus,
Subcapsular cataract,
Temporal optic disc pallor,
Thinning of Descemet membrane,
Visual impairment,
Visual loss
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Mouse (7 sources):
abnormal canal of Schlemm morphology,
abnormal iridocorneal angle,
abnormal trabecular meshwork morphology,
absent Schlemm's canal,
decreased incidence of tumors by chemical induction,
decreased physiological sensitivity to xenobiotic,
hypoplastic trabecular meshwork
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.