yap1 Phenotypes

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Phenotypes

Gene Literature (33)

Nucleotides (211)

Interactants (616)

XB-GENEPAGE-952393

Gene Symbol: yap1 Gene Name: Yes associated protein 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal neural crest (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: yap1 manipulated (4 sources)
Computed annotations: yap1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + yap1 MO (2 sources), Xla Wt + wnt8a + yap1 MO (1 source), Xla Wt + yap1 MO + BIO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (20 sources): Cataract, Chorioretinal coloboma, Cleft palate, Cleft upper lip, Coloboma, Corneal opacity, Glaucoma, Hematuria, Intellectual disability, Iris coloboma, Microphthalmia, Nystagmus, Optic atrophy, Posterior embryotoxon, Ptosis, Retinal detachment, Sensorineural hearing impairment, Strabismus, Visual impairment, obsolete Bilateral cleft lip and palate [+]
Mouse (63 sources): abnormal atrial thrombosis, abnormal bile duct development, abnormal bile duct morphology, abnormal dorsal-ventral axis patterning, abnormal embryo development, abnormal embryonic tissue morphology, abnormal enterocyte proliferation, abnormal epidermal stem cell morphology, abnormal epidermis stratum basale morphology, abnormal epidermis stratum corneum morphology, abnormal hepatocyte morphology, abnormal kidney development, abnormal kidney papilla morphology, abnormal loop of Henle morphology, abnormal metanephros morphology, abnormal myocardium layer morphology, abnormal nephrogenic zone morphology, abnormal posterior primitive streak morphology, abnormal proximal convoluted tubule morphology, abnormal renal glomerulus morphology, abnormal renal tubule morphology, abnormal rostral-caudal body axis extension, abnormal skin condition, abnormal ventral body wall morphology, abnormal visceral yolk sac morphology, absent visceral yolk sac blood islands, cardiac fibrosis, decreased cardiac muscle contractility, decreased cell proliferation, decreased embryo size, decreased renal glomerulus number, decreased renal tubule number, digestive/alimentary phenotype, dilated heart ventricle, disorganized yolk sac vascular plexus, embryonic lethality during organogenesis, complete penetrance, embryonic-extraembryonic boundary constriction, excessive folding of visceral yolk sac, impaired branching involved in ureteric bud morphogenesis, impaired skin barrier function, incomplete embryo turning, increased cell proliferation, increased circulating alanine transaminase level, increased enterocyte apoptosis, increased hepatocyte apoptosis, increased hepatocyte proliferation, increased incidence of tumors by chemical induction, increased myocardial infarct size, increased sensitivity to xenobiotic induced morbidity/mortality, increased susceptibility to induced colitis, increased susceptibility to weight loss, macrovesicular hepatic steatosis, neonatal lethality, complete penetrance, pale liver, podocyte foot process effacement, postnatal lethality, complete penetrance, premature death, preweaning lethality, complete penetrance, thick myocardium, thin epidermis, thin epidermis stratum basale, thin myocardium, thin ventricular wall [+]
View all ortholog results at Monarch