| Monarch Ortholog Phenotypes
|
|
Human (5 sources):
Desquamation of skin soon after birth,
Eosinophilia,
Ichthyosis,
Neonatal respiratory distress,
Premature birth
|
Mouse (29 sources):
abnormal breathing pattern,
abnormal dermal layer morphology,
abnormal digestive system morphology,
abnormal epidermal-dermal junction morphology,
abnormal epidermis stratum corneum morphology,
abnormal epidermis stratum spinosum morphology,
abnormal keratohyalin granule morphology,
abnormal locomotor activation,
abnormal pilosebaceous unit morphology,
abnormal postnatal growth/weight/body size,
abnormal pulmonary alveolus morphology,
abnormal skin appearance,
abnormal skin condition,
abnormal suckling behavior,
absent gastric milk in neonates,
absent suckling reflex,
decreased hair follicle number,
decreased keratohyalin granule size,
decreased locomotor activity,
embryonic lethality, complete penetrance,
epidermal necrosis,
impaired skin barrier function,
increased keratinocyte proliferation,
joint contracture,
neonatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
shiny skin,
thick pulmonary interalveolar septum,
thick skin
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.