Monarch Ortholog Phenotypes
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Human (13 sources):
Anemia,
Autoimmunity,
Decreased circulating IgG level,
Elevated erythrocyte sedimentation rate,
Hepatomegaly,
Lymphadenopathy,
Lymphoma,
Pancytopenia,
Recurrent aphthous stomatitis,
Recurrent infections,
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Mouse (32 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal CD8-positive, alpha-beta T cell physiology,
abnormal NK T cell morphology,
abnormal T cell activation,
abnormal cell proliferation,
abnormal gamma-delta T cell morphology,
abnormal positive T cell selection,
abnormal thymus cell ratio,
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
decreased CD4-positive, alpha beta T cell number,
decreased CD8-positive, alpha-beta memory T cell number,
decreased CD8-positive, naive alpha-beta T cell number,
decreased NK T cell number,
decreased T cell proliferation,
decreased interferon-gamma secretion,
decreased interleukin-2 secretion,
immune system phenotype,
increased CD8-positive, alpha-beta T cell number,
increased CD8-positive, alpha-beta memory T cell proliferation,
increased central memory CD4-positive, alpha-beta T cell number,
increased central memory CD8 positive, alpha-beta T cell number,
increased double-negative T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased germinal center B cell number,
increased interferon-gamma secretion,
increased interleukin-10 secretion,
increased interleukin-13 secretion,
increased interleukin-4 secretion,
increased mature gamma-delta T cell number,
increased memory T cell number,
increased susceptibility to parasitic infection
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View all ortholog results at Monarch
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