| Monarch Ortholog Phenotypes
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Human (2 sources):
Abnormality of the respiratory system,
Alveolar cell carcinoma
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Mouse (29 sources):
abnormal colon morphology,
abnormal dendritic cell antigen presentation,
abnormal enterocyte apoptosis,
abnormal enterocyte proliferation,
abnormal response to infection,
decreased IgG1 level,
decreased colon length,
decreased interferon-alpha secretion,
decreased interferon-beta secretion,
decreased interleukin-1 beta secretion,
decreased interleukin-6 secretion,
decreased macrophage cytokine production,
decreased sensitivity to xenobiotic induced morbidity/mortality,
decreased spleen weight,
decreased susceptibility to endotoxin shock,
decreased tumor necrosis factor secretion,
homeostasis/metabolism phenotype,
immune system phenotype,
impaired natural killer cell mediated cytotoxicity,
increased IgG2a level,
increased T cell derived lymphoma incidence,
increased T cell proliferation,
increased incidence of tumors by chemical induction,
increased interleukin-12b secretion,
increased physiological sensitivity to xenobiotic,
increased sensitivity to xenobiotic induced morbidity/mortality,
increased susceptibility to weight loss,
increased tumor growth/size,
prenatal lethality, incomplete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.