vangl2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-973459

Gene Symbol: vangl2 Gene Name: VANGL planar cell polarity protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal neural tube closure (4 sources), decreased length of anterior-posterior axis (3 sources), abnormally delayed closure of blastopore (2 sources), abnormal bending of dorsal trunk (1 source), abnormal cell migration (1 source), abnormal convergent extension involved in axis elongation (1 source), abnormal development of upper blastopore lip (1 source), abnormal establishment of epithelial cell planar polarity (1 source), abnormally increased number of multiciliated cell (1 source), absent blastopore (1 source), absent epidermis outer layer (1 source), absent multiciliated cell (1 source), decreased length of dorsal-ventral axis (1 source), increased thickness of the ectoderm (1 source), increased thickness of the epidermis (1 source), increased thickness of the neural plate (1 source), increased thickness of the non-neural ectoderm (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal neural tube closure (4 sources), decreased length of anterior-posterior axis (3 sources), abnormally delayed closure of blastopore (2 sources), abnormal bending of dorsal trunk (1 source), abnormal cell migration (1 source), abnormal convergent extension involved in axis elongation (1 source), abnormal development of upper blastopore lip (1 source), abnormal establishment of epithelial cell planar polarity (1 source), abnormally increased number of multiciliated cell (1 source), absent blastopore (1 source), absent epidermis outer layer (1 source), absent multiciliated cell (1 source), decreased length of dorsal-ventral axis (1 source), increased thickness of the ectoderm (1 source), increased thickness of the epidermis (1 source), increased thickness of the neural plate (1 source), increased thickness of the non-neural ectoderm (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: vangl2 manipulated (7 sources), vangl2 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + vangl2 MO (9 sources), Xla Wt + vangl2 MO (3 sources), Xla Wt + vangl2 MO (3 sources), Xla wt + vangl2 mRNA (2 sources), Xla Wt + HA-vangl2T76>A,T78>A (1 source), Xla Wt + sqstm1 MO + vangl2 MO (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (10 sources): Absence of the sacrum, Anencephaly, Asymmetry of spinal facet joints, Hydrocephalus, Lipoma, Multiple lipomas, Myelomeningocele, Sacral dimple, Spina bifida occulta, Urinary incontinence
Mouse (105 sources): aberrant origin of the right subclavian artery, abnormal Deiters cell morphology, abnormal body wall morphology, abnormal brain development, abnormal brain ventricle morphology, abnormal brain ventricular system morphology, abnormal branching involved in lung morphogenesis, abnormal cerebral hemisphere morphology, abnormal cervical flexure morphology, abnormal cochlea morphology, abnormal cochlear hair cell morphology, abnormal cochlear inner hair cell morphology, abnormal cochlear outer hair cell morphology, abnormal costovertebral joint morphology, abnormal digestive system development, abnormal distortion product otoacoustic emission, abnormal dorsal striatum morphology, abnormal ear development, abnormal embryo development, abnormal embryo turning, abnormal embryonic neuroepithelium morphology, abnormal embryonic tissue morphology, abnormal forebrain development, abnormal heart development, abnormal heart looping, abnormal left subclavian artery morphology, abnormal locomotor behavior, abnormal lung epithelium morphology, abnormal lung lobe morphology, abnormal lung saccule morphology, abnormal midbrain development, abnormal motor capabilities/coordination/movement, abnormal neural plate morphology, abnormal notochord morphology, abnormal organ of Corti morphology, abnormal orientation of cochlear hair cell stereociliary bundles, abnormal orientation of inner hair cell stereociliary bundles, abnormal orientation of outer hair cell stereociliary bundles, abnormal otic pit morphology, abnormal otic vesicle development, abnormal pillar cell morphology, abnormal primitive streak morphology, abnormal respiratory conducting tube morphology, abnormal rib development, abnormal snout morphology, abnormal somite development, abnormal somite shape, abnormal somite size, abnormal sternebra morphology, abnormal sternocostal joint morphology, abnormal sternum morphology, abnormal sternum ossification, abnormal tail morphology, abnormal tail movements, abnormal ventral body wall morphology, abnormal vertebral arch development, abnormal vertebral arch morphology, abnormal vertebral body morphology, abnormal vertebral epiphyseal plate morphology, abnormal vestibular hair cell morphology, abnormal xiphoid process morphology, behavior/neurological phenotype, common truncal valve, curly tail, decreased embryo size, decreased fetal size, decreased vertical activity, delayed neural tube closure, dilated endolymphatic sac, dilated terminal bronchiole tube, embryo phenotype, enlarged floor plate, enlarged lateral ventricles, enlarged third ventricle, eyelids open at birth, failure of eyelid fusion, fetal growth retardation, fused somites, fusion of vertebral arches, head shaking, hearing/vestibular/ear phenotype, impaired balance, impaired branching involved in terminal bronchiole morphogenesis, incomplete embryo turning, increased circulating glucose level, increased cochlear hair cell number, increased cochlear outer hair cell number, increased or absent threshold for auditory brainstem response, inner ear hypoplasia, kinked tail, lethality, complete penetrance, limbs/digits/tail phenotype, neonatal lethality, incomplete penetrance, nervous system phenotype, open neural tube, perinatal lethality, complete penetrance, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, short scala media, short tail, skeleton phenotype, small lung, small lung lobe, thick lung-associated mesenchyme, vision/eye phenotype [+]
View all ortholog results at Monarch