| Monarch Ortholog Phenotypes
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Human (21 sources):
Asthma,
Biliary cirrhosis,
Bronchiectasis,
Chronic lung disease,
Cor pulmonale,
Decreased circulating antibody level,
Dehydration,
Elevated sweat chloride,
Exocrine pancreatic insufficiency,
Failure to thrive,
Hepatomegaly,
Hypercalciuria,
Immunodeficiency,
Malabsorption,
Male infertility,
Meconium ileus,
Pulmonary fibrosis,
Rectal prolapse,
Recurrent bronchopulmonary infections,
Recurrent pneumonia,
Recurrent respiratory infections
[+]
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Mouse (30 sources):
abnormal cued conditioning behavior,
abnormal depression-related behavior,
abnormal excitatory postsynaptic potential,
abnormal grip strength,
abnormal hypothalamus secretion,
abnormal latent inhibition of conditioning behavior,
abnormal neuron physiology,
abnormal response to novel object,
abnormal social investigation,
abnormal spatial working memory,
abnormal synaptic vesicle number,
abnormal synaptic vesicle recycling,
behavior/neurological phenotype,
decreased anxiety-related response,
decreased fetal size,
decreased grip strength,
decreased synaptic depression,
decreased total retina thickness,
embryonic growth retardation,
enhanced paired-pulse facilitation,
impaired contextual conditioning behavior,
impaired synaptic plasticity,
increased post-tetanic potentiation,
increased serotonin level,
increased startle reflex,
lethality at weaning, incomplete penetrance,
lethality throughout fetal growth and development, incomplete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
reduced long term potentiation
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.