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Summary Expression Phenotypes Gene Literature (30) GO Terms (10) Nucleotides (228) Proteins (75) Interactants (626) Wiki

dvl3     dishevelled segment polarity protein 3

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of pronephric kidney (1 source), abnormal pronephric kidney morphology (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dvl3 manipulated (2 sources)
Computed annotations: dvl3 assayed (2 sources)
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
nephronophthisis 2 (1AP source)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + bmp2 + dvl3 MO (1 source), Xla Wt + dvl2 MO + dvl3 MO (1 source), Xla Wt + dvl3 MO + dvl1 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (98 sources): Abnormal form of the vertebral bodies, Abnormal penis morphology, Abnormality of the gingiva, Agenesis of permanent teeth, Anodontia, Anteriorly placed anus, Anteverted nares, Avascular necrosis of the capital femoral epiphysis, Bifid tongue, Blue sclerae, [+]
Mouse (4 sources): abnormal orientation of cochlear hair cell stereociliary bundles, double outlet right ventricle, ventricular defect committed to aorta, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance

View all ortholog results at Monarch