xpa Phenotypes

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Phenotypes

Gene Literature (16)

Nucleotides (98)

Interactants (456)

XB-GENEPAGE-977980

Gene Symbol: xpa Gene Name: xeroderma pigmentosum, complementation group A

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (65 sources): Abnormality of extrapyramidal motor function, Abnormality of the dentition, Aminoaciduria, Ankyloblepharon, Arthralgia, Ataxia, Blepharitis, Cataract, Cerebral cortical atrophy, Choreoathetosis, Cognitive impairment, Conjunctival telangiectasia, Conjunctivitis, Craniofacial hyperostosis, Cryptorchidism, Cutaneous photosensitivity, Decreased testicular size, Defective DNA repair after ultraviolet radiation damage, Delayed skeletal maturation, Dermal atrophy, Developmental regression, Dry skin, EEG abnormality, Ectropion, Entropion, Erythema, Failure to thrive, Fatigue, Fever, Flat nasal alae, Freckling, Hearing impairment, Hyperkeratosis, Hypermelanotic macule, Hypogonadism, Hypopigmented skin patches, Hyporeflexia, Intellectual disability, Intellectual disability, progressive, Keratitis, Macule, Melanocytic nevus, Melanoma, Mental deterioration, Microcephaly, Neoplasm, Neoplasm of the eye, Opacification of the corneal stroma, Optic atrophy, Papilloma, Peripheral neuropathy, Photophobia, Poikiloderma, Pterygium, Reduced tendon reflexes, Seizure, Sensorineural hearing impairment, Short stature, Spasticity, Strabismus, Telangiectasia, Telangiectasia of the skin, Thickened skin, Thin skin, obsolete Hypotrichosis [+]
Mouse (26 sources): abnormal Langerhans cell physiology, abnormal base-excision repair, abnormal epididymis morphology, abnormal lymphocyte physiology, abnormal seminiferous tubule epithelium morphology, acanthosis, decreased cellular sensitivity to ultraviolet irradiation, decreased testis weight, embryonic lethality during organogenesis, incomplete penetrance, fetal growth retardation, impaired hematopoiesis, increased NK cell number, increased cellular sensitivity to ultraviolet irradiation, increased incidence of induced tumors, increased incidence of tumors by UV-induction, increased incidence of tumors by chemical induction, increased liver adenoma incidence, increased liver tumor incidence, increased lung adenoma incidence, increased papilloma incidence, increased prostaglandin level, increased tumor incidence, reduced male fertility, seminiferous tubule degeneration, skin edema, small liver [+]
View all ortholog results at Monarch