abnormal humoral immune response, abnormal immune system organ morphology, abnormal lipid level, abnormal male germ cell apoptosis, abnormal memory B cell morphology, abnormal memory B cell physiology, abnormal professional antigen presenting cell physiology, abnormal somatic hypermutation frequency, abnormal spleen germinal center morphology, absent germinal center B cells, absent spleen germinal center, adipose tissue inflammation, cardiac interstitial fibrosis, decreased B cell proliferation, decreased IgG1 level, decreased IgG2a level, decreased T follicular helper cell number, decreased adipocyte glucose uptake, decreased body size, decreased bone marrow cell number, decreased ceramide level, decreased circulating free fatty acids level, decreased fasting circulating glucose level, decreased germinal center B cell number, decreased interleukin-4 secretion, decreased liver triglyceride level, decreased liver weight, decreased respiratory quotient, decreased spleen germinal center number, decreased susceptibility to hepatic steatosis, dilated heart ventricle, growth/size/body region phenotype, heart inflammation, immune system phenotype, increased adipocyte glucose uptake, increased body fat mass, increased circulating adiponectin level, increased insulin sensitivity, increased interleukin-10 secretion, increased lipogenesis, increased muscle cell glucose uptake, increased subcutaneous adipose tissue amount, increased susceptibility to diet-induced obesity, increased white adipose tissue amount, increased white fat cell size, myocardial fiber degeneration, no abnormal phenotype detected, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, incomplete penetrance, reduced male fertility, small thymus, spleen hyperplasia, thin ventricular wall