| Monarch Ortholog Phenotypes
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Human (31 sources):
Buphthalmos,
Choanal atresia,
Cholestasis,
Congenital hypothyroidism,
Depressed nasal bridge,
Developmental glaucoma,
Diabetes mellitus,
Epicanthus,
Global developmental delay,
Hepatic fibrosis,
Hepatitis,
Hepatomegaly,
Hiatus hernia,
Intrauterine growth retardation,
Long philtrum,
Low-set ears,
Osteopenia,
Pancreatic cysts,
Pancreatic hypoplasia,
Polycystic kidney dysplasia,
Portal hypertension,
Recurrent infections,
Renal cyst,
Sagittal craniosynostosis,
Sensorineural hearing impairment,
Splenic cyst,
Splenomegaly,
Thin upper lip vermilion,
Thoracolumbar scoliosis,
Umbilical hernia,
Wide anterior fontanel
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Mouse (18 sources):
abnormal pancreatic islet morphology,
abnormal renal tubule epithelial cell primary cilium morphology,
absent pancreatic alpha cells,
absent pancreatic beta cells,
decreased birth weight,
decreased body size,
decreased insulin secretion,
decreased pancreatic alpha cell number,
decreased pancreatic delta cell number,
decreased pancreatic epsilon cell number,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.