| Monarch Ortholog Phenotypes
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Human (43 sources):
Arthralgia,
Arthralgia of the hip,
Bowing of the legs,
Broad femoral neck,
Coxa vara,
Delayed ossification of carpal bones,
Delayed tarsal ossification,
Disproportionate short-limb short stature,
Dysplastic iliac wing,
Enlarged joints,
Epiphyseal dysplasia,
Flat acetabular roof,
Flat face,
Gait disturbance,
Genu valgum,
Genu varum,
Hip dysplasia,
Hypoplasia of the capital femoral epiphysis,
Hypoplastic pubic bone,
Irregular epiphyses,
Joint stiffness,
Limitation of joint mobility,
Limited elbow extension,
Lumbar hyperlordosis,
Metaphyseal irregularity,
Metaphyseal spurs,
Metaphyseal widening,
Micromelia,
Multiple epiphyseal dysplasia,
Narrow iliac wing,
Osteoarthritis,
Ovoid vertebral bodies,
Pectus excavatum,
Platyspondyly,
Posterior rib cupping,
Premature osteoarthritis,
Short femoral neck,
Short long bone,
Short stature,
Small epiphyses,
Spondyloepimetaphyseal dysplasia,
Thoracic hypoplasia,
Waddling gait
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Mouse (9 sources):
abnormal chondrocyte morphology,
abnormal long bone epiphyseal plate morphology,
abnormal long bone epiphyseal plate proliferative zone,
abnormal long bone hypertrophic chondrocyte zone,
decreased chondrocyte proliferation,
disproportionate dwarf,
increased bone mass,
increased chondrocyte apoptosis,
skeleton phenotype
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.