alms1 Phenotypes

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Phenotypes

Gene Literature (2)

Nucleotides (188)

Interactants (125)

XB-GENEPAGE-988074

Gene Symbol: alms1 Gene Name: ALMS1, centrosome and basal body associated protein

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: alms1 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (82 sources): Abnormal adipose tissue morphology, Abnormal chorioretinal morphology, Abnormal female external genitalia morphology, Abnormality of the dentition, Abnormality of the hand, Abnormality of the menstrual cycle, Abnormality of the urethra, Acanthosis nigricans, Accelerated skeletal maturation, Aplasia/Hypoplasia of the cerebellum, Asthma, Atherosclerosis, Autism, Blindness, Cataract, Chronic active hepatitis, Chronic hepatic failure, Chronic otitis media, Cirrhosis, Compulsive behaviors, Cone/cone-rod dystrophy, Congestive heart failure, Constriction of peripheral visual field, Decreased HDL cholesterol concentration, Decreased response to growth hormone stimulation test, Decreased testicular size, Deeply set eye, Depression, Diabetes insipidus, Dilated cardiomyopathy, Elevated circulating hepatic transaminase concentration, Generalized hirsutism, Gingivitis, Global developmental delay, Glomerulopathy, Gynecomastia, Hepatic steatosis, Hepatomegaly, Hypergonadotropic hypogonadism, Hyperinsulinemia, Hyperostosis frontalis interna, Hypertension, Hypertriglyceridemia, Hyperuricemia, Hypothyroidism, Insulin resistance, Insulin-resistant diabetes mellitus, Intellectual disability, Kyphosis, Male hypogonadism, Multinodular goiter, Nephritis, Nephrocalcinosis, Nystagmus, Otitis media, Pes planus, Photophobia, Pigmentary retinopathy, Polycystic ovaries, Portal hypertension, Precocious puberty, Progressive sensorineural hearing impairment, Progressive visual loss, Pulmonary arterial hypertension, Pulmonary fibrosis, Recurrent pneumonia, Recurrent respiratory infections, Renal insufficiency, Renovascular hypertension, Respiratory insufficiency, Round face, Scoliosis, Seizure, Short stature, Splenomegaly, Subcapsular cataract, Truncal obesity, Tubulointerstitial nephritis, Type II diabetes mellitus, Vesicoureteral reflux, Visual loss, obsolete Hypotrichosis [+]
Mouse (32 sources): abnormal circulating cholesterol level, abnormal eye electrophysiology, abnormal hepatocyte morphology, abnormal locomotor behavior, abnormal proximal convoluted tubule morphology, abnormal renal tubule epithelial cell primary cilium morphology, abnormal retina outer nuclear layer morphology, abnormal seminiferous tubule morphology, cellular phenotype, crystalluria, decreased eosinophil cell number, degranulated pancreatic beta cells, dilated proximal convoluted tubule, dilated renal tubules, increased body size, increased fasting circulating glucose level, increased food intake, increased kidney apoptosis, increased kidney cell proliferation, increased kidney weight, increased liver weight, increased or absent threshold for auditory brainstem response, increased susceptibility to weight gain, increased total body fat amount, increased white adipose tissue amount, macrovesicular hepatic steatosis, microvesicular hepatic steatosis, pancreatic islet hyperplasia, retina outer nuclear layer degeneration, retina photoreceptor degeneration, retina pigment epithelium atrophy, seminiferous tubule degeneration [+]
View all ortholog results at Monarch