Monarch Ortholog Phenotypes
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Mouse (35 sources):
abnormal T cell activation,
abnormal T cell differentiation,
abnormal T cell subpopulation ratio,
abnormal double-negative T cell morphology,
abnormal double-positive T cell morphology,
abnormal effector T cell morphology,
abnormal negative T cell selection,
abnormal platelet activation,
abnormal positive T cell selection,
abnormal thymocyte activation,
abnormal vitreous body morphology,
arrested T cell differentiation,
autoimmune response,
decreased CD4-positive, alpha beta T cell number,
decreased NK T cell number,
decreased T cell apoptosis,
decreased T cell proliferation,
decreased double-negative T cell number,
decreased double-positive T cell number,
decreased interferon-gamma secretion,
decreased interleukin-2 secretion,
decreased locomotor activity,
decreased single-positive T cell number,
decreased thymocyte number,
immune system phenotype,
impaired natural killer cell mediated cytotoxicity,
increased CD8-positive, alpha-beta T cell number,
increased NK cell number,
increased anxiety-related response,
increased double-negative T cell number,
increased gamma-delta T cell number,
increased thigmotaxis,
perinatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
small thymus
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