ciita Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (51)

Interactants (105)

XB-GENEPAGE-992717

Gene Symbol: ciita Gene Name: class II, major histocompatibility complex, transactivator

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (52 sources): Abnormal CD4:CD8 ratio, Abnormal facial shape, Abnormality of humoral immunity, Acute otitis media, Agammaglobulinemia, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, Autoimmunity, Biliary tract abnormality, Cholangitis, Chronic hepatitis due to cryptosporidium infection, Chronic lymphocytic meningitis, Chronic mucocutaneous candidiasis, Colitis, Cutaneous anergy, Decreased circulating antibody level, Decreased circulating beta-2-microglobulin level, Decreased lymphocyte proliferation in response to mitogen, Decreased proportion of CD4-positive helper T cells, Diarrhea, Dysarthria, Failure to thrive, Gait ataxia, Infectious encephalitis, Lack of T cell function, Malabsorption, Myopia, Neutropenia, Neutropenia in presence of anti-neutropil antibodies, Pancytopenia, Panhypogammaglobulinemia, Protracted diarrhea, Recurrent Staphylococcus aureus infections, Recurrent bacterial infections, Recurrent candida infections, Recurrent fungal infections, Recurrent herpes, Recurrent infection of the gastrointestinal tract, Recurrent lower respiratory tract infections, Recurrent protozoan infections, Recurrent respiratory infections, Recurrent upper respiratory tract infections, Recurrent urinary tract infections, Recurrent viral infections, Reduced MHC II surface expression, Rhinitis, Sclerosing cholangitis, Sinusitis, Skin rash, T lymphocytopenia, Villous atrophy, Viral hepatitis [+]
Mouse (33 sources): abnormal CD4-positive T cell differentiation, abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal MHC II cell surface expression on macrophages, abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal T-helper 1 physiology, abnormal dendritic cell physiology, abnormal level of surface class II molecules, abnormal lymphocyte physiology, abnormal popliteal lymph node morphology, abnormal susceptibility to infection, absent CD4-positive, alpha beta T cells, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased bone trabecula number, decreased dendritic cell number, decreased susceptibility to autoimmune diabetes, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased susceptibility to parasitic infection, decreased trabecular bone volume, immune system phenotype, impaired humoral immune response, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased bone trabecular spacing, increased circulating type I collagen C-terminal telopeptide level, increased double-positive T cell number, increased osteoclast cell number, increased susceptibility to parasitic infection, insulitis, no abnormal phenotype detected, periinsulitis [+]
View all ortholog results at Monarch