Monarch Ortholog Phenotypes
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Human (31 sources):
Abnormal autonomic nervous system physiology,
Abnormal pyramidal sign,
Abnormality of extrapyramidal motor function,
Babinski sign,
Bradykinesia,
Cognitive impairment,
Dementia,
Dysarthria,
Dysphagia,
Dystonia,
Hyperreflexia,
Hypomimic face,
Intention tremor,
Lewy bodies,
Lower limb spasticity,
Monotonic speech,
Myoclonus,
Neurogenic bladder,
Parkinsonism,
Parkinsonism with favorable response to dopaminergic medication,
Postural instability,
Rigidity,
Scissor gait,
Shuffling gait,
Sleep disturbance,
Slow saccadic eye movements,
Spasticity,
Substantia nigra gliosis,
Talipes equinovarus,
Tremor,
Visual hallucinations
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Mouse (40 sources):
abnormal T cell differentiation,
abnormal circulating fructosamine level,
abnormal circulating iron level,
abnormal effector T cell number,
abnormal erythrocyte cell number,
abnormal hematocrit,
abnormal hemoglobin content,
abnormal proerythroblast morphology,
abnormal red blood cell distribution width,
abnormal reticulocyte cell number,
arrest of spermiogenesis,
behavior/neurological phenotype,
decreased CD4-positive, alpha beta T cell number,
decreased circulating alanine transaminase level,
decreased circulating fructosamine level,
decreased circulating iron level,
decreased erythroblast number,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased testis weight,
hematopoietic system phenotype,
immotile sperm,
immune system phenotype,
increased activated T cell number,
increased double-negative T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased effector memory CD8-positive, alpha-beta T cell number,
increased erythroblast number,
increased erythrocyte clearance,
increased lean body mass,
increased mean corpuscular hemoglobin,
increased mean corpuscular hemoglobin concentration,
increased memory T cell number,
increased pro-B cell number,
increased red blood cell distribution width,
increased spleen weight,
increased susceptibility to bacterial infection induced morbidity/mortality,
postnatal lethality, complete penetrance,
thymus atrophy
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View all ortholog results at Monarch
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