Monarch Ortholog Phenotypes
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Mouse (35 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology,
abnormal T cell differentiation,
abnormal memory T cell morphology,
abnormal negative T cell selection,
abnormal positive T cell selection,
abnormal regulatory T cell morphology,
abnormal thymus medulla morphology,
decreased B-1a cell number,
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
decreased CD4-positive, alpha beta T cell number,
decreased CD8-positive, alpha-beta memory T cell number,
decreased CD8-positive, naive alpha-beta T cell number,
decreased T cell proliferation,
decreased alpha-beta T cell number,
decreased regulatory T cell number,
decreased single-positive T cell number,
decreased splenocyte number,
decreased thymocyte number,
immune system phenotype,
impaired hematopoiesis,
impaired humoral immune response,
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased CD8-positive, alpha-beta T cell number,
increased CD8-positive, alpha-beta memory T cell number,
increased NK T cell number,
increased T cell proliferation,
increased central memory CD4-positive, alpha-beta T cell number,
increased central memory CD8 positive, alpha-beta T cell number,
increased double-positive T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased effector memory CD8-positive, alpha-beta T cell number,
increased memory T cell number,
small thymus medulla
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