spo11 Phenotypes

Phenotypes

XB-GENEPAGE-995589

Gene Symbol: spo11 Gene Name: SPO11 initiator of meiotic double strand breaks

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: spo11 assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (28 sources): abnormal X-Y chromosome synapsis during male meiosis, abnormal chromosomal synapsis, abnormal double-strand DNA break repair, abnormal female meiosis, abnormal female reproductive system morphology, abnormal fertility/fecundity, abnormal gametogenesis, abnormal male meiosis, abnormal meiosis, abnormal oogenesis, abnormal primordial ovarian follicle morphology, abnormal seminiferous tubule morphology, abnormal spermatid morphology, abnormal synaptonemal complex, abnormal uterus development, absent mature ovarian follicles, arrest of male meiosis, arrest of spermatogenesis, decreased mature ovarian follicle number, decreased oocyte number, decreased ovary weight, decreased testis weight, early reproductive senescence, immune system phenotype, impaired ovarian folliculogenesis, oocyte degeneration, small ovary, small seminiferous tubules [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (28 sources): abnormal X-Y chromosome synapsis during male meiosis, abnormal chromosomal synapsis, abnormal double-strand DNA break repair, abnormal female meiosis, abnormal female reproductive system morphology, abnormal fertility/fecundity, abnormal gametogenesis, abnormal male meiosis, abnormal meiosis, abnormal oogenesis, [+]