tph1 Phenotypes

Phenotypes

XB-GENEPAGE-996925

Gene Symbol: tph1 Gene Name: tryptophan hydroxylase 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tph1 assayed (4 sources)
Computed annotations: tph1 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (16 sources): abnormal heart left ventricle pressure, abnormal serotonin level, behavior/neurological phenotype, decreased cardiac muscle contractility, decreased cardiac output, decreased cardiac stroke volume, decreased pancreatic beta cell mass, decreased pancreatic beta cell proliferation, decreased physiological sensitivity to xenobiotic, decreased serotonin level, homeostasis/metabolism phenotype, increased bone mass, increased bone ossification, increased osteoblast cell number, increased osteoblast proliferation, skeleton phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (16 sources): abnormal heart left ventricle pressure, abnormal serotonin level, behavior/neurological phenotype, decreased cardiac muscle contractility, decreased cardiac output, decreased cardiac stroke volume, decreased pancreatic beta cell mass, decreased pancreatic beta cell proliferation, decreased physiological sensitivity to xenobiotic, decreased serotonin level, [+]