| Monarch Ortholog Phenotypes
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Human (52 sources):
Abnormal circulating cholesterol concentration,
Abnormal sex determination,
Abnormal spermatogenesis,
Abnormal urine potassium concentration,
Abnormal vagina morphology,
Abnormality of prenatal development or birth,
Abnormality of the menstrual cycle,
Absence of secondary sex characteristics,
Acidosis,
Adrenocortical adenoma,
Adrenocorticotropic hormone excess,
Adrenogenital syndrome,
Ambiguous genitalia, male,
Congenital adrenal hyperplasia,
Cryptorchidism,
Decreased circulating androgen concentration,
Decreased circulating cortisol level,
Decreased fertility,
Decreased fertility in females,
Decreased fertility in males,
Decreased testicular size,
Dehydration,
Delayed puberty,
Delayed skeletal maturation,
Ectopic adrenal gland,
Elevated circulating follicle stimulating hormone level,
Elevated circulating luteinizing hormone level,
Failure to thrive,
Feeding difficulties,
Female external genitalia in individual with 46,XY karyotype,
Generalized hyperpigmentation,
Gynecomastia,
Hypercholesterolemia,
Hyperkalemia,
Hypernatriuria,
Hyponatremia,
Hypospadias,
Hypotension,
Hypovolemia,
Increased circulating ACTH level,
Increased circulating renin level,
Male pseudohermaphroditism,
Neonatal hypoglycemia,
Osteoporosis,
Primary adrenal insufficiency,
Reduced bone mineral density,
Renal salt wasting,
Sex reversal,
Short stature,
Urogenital sinus anomaly,
Vomiting,
obsolete Decreased circulating aldosterone level
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Mouse (13 sources):
abnormal adrenal cortex morphology,
abnormal ovarian folliculogenesis,
abnormal uterus morphology,
absent corpus luteum,
adrenal cortical hyperplasia,
arrest of spermatogenesis,
increased adrenocorticotropin level,
increased circulating corticotropin-releasing hormone level,
neonatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.