The gene phf19 encodes a transcription factor with a PHD domain, functioning as a component of the polycomb repressive complex 2 (PRC2) which facilitates histone methylation, specifically tri-methylati...[+]

The gene phf19 encodes a transcription factor with a PHD domain, functioning as a component of the polycomb repressive complex 2 (PRC2) which facilitates histone methylation, specifically tri-methylation of lysine 27 on histone H3 (H3K27me3). It binds histone H3 and is involved in transcriptional repression. The protein localizes to the nucleus. Its expression and function are associated with development of the eye, including the lens and retina, the forebrain, the midbrain-hindbrain boundary, and neural crest cells. [-]

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