S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2''-O-ribose methylation to the 5''-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped...[+]

S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2''-O-ribose methylation to the 5''-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD