The cd28 gene encodes a type i transmembrane protein and is a member of the immunoglobulin superfamily, functioning as a t-cell co-stimulatory receptor. Its protein localizes to the cell surface and up...[+]

The cd28 gene encodes a type i transmembrane protein and is a member of the immunoglobulin superfamily, functioning as a t-cell co-stimulatory receptor. Its protein localizes to the cell surface and upon binding its ligand, it provides a signal necessary for full t-cell activation, proliferation, and cytokine production. Expression is detected in lymphoid tissues including the spleen and thymus. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD