The acly protein is an atp-citrate lyase enzyme that catalyzes the conversion of citrate to acetyl-coa, a fundamental precursor for de novo lipid synthesis including fatty acids and sterols. This cytos...[+]

The acly protein is an atp-citrate lyase enzyme that catalyzes the conversion of citrate to acetyl-coa, a fundamental precursor for de novo lipid synthesis including fatty acids and sterols. This cytosolic enzyme supports membrane biosynthesis during early development, with its mrna and protein detected in oocytes and throughout embryogenesis, particularly associated with neural tissues, the eye, and pronephros. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD