The h2az1 gene encodes a replication-independent histone variant protein, specifically an h2a.z histone. This protein localizes to the nucleus where it incorporates into nucleosomes and functions in ch...[+]

The h2az1 gene encodes a replication-independent histone variant protein, specifically an h2a.z histone. This protein localizes to the nucleus where it incorporates into nucleosomes and functions in chromatin organization for transcriptional regulation. It is involved in processes including dna repair and chromosome segregation during cell division. Expression is documented during oogenesis and spermatogenesis, with transcripts present in the ovary and testis, and also detected in the brain, eye, and pronephros. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD