xbp1 encodes a bZIP transcription factor that, upon endoplasmic reticulum stress, is activated by IRE1-mediated splicing, leading to nuclear translocation where it regulates genes involved in the unfol...[+]

xbp1 encodes a bZIP transcription factor that, upon endoplasmic reticulum stress, is activated by IRE1-mediated splicing, leading to nuclear translocation where it regulates genes involved in the unfolded protein response, including chaperones and ER-associated degradation components; in Xenopus laevis and Xenopus tropicalis, it is involved in notochord development and neural tube formation, with expression in the notochord and neural tube. [-]

          MAJOR AFFECTIVE DISORDER 7; MAFD7

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD