The wnt1 gene encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. In Xenopus laevis and Xenopus tropicalis, wnt1 is involved in embryonic development, includin...[+]

The wnt1 gene encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. In Xenopus laevis and Xenopus tropicalis, wnt1 is involved in embryonic development, including neural tube formation, brain development, and somite patterning. It acts through the canonical Wnt/β-catenin pathway to regulate gene expression, influencing cell fate decisions during embryogenesis. The protein is secreted and can act as a morphogen to pattern tissues during early development. [-]

             osteogenesis imperfecta type 4
             osteogenesis imperfecta type 15

          OSTEOGENESIS IMPERFECTA, TYPE XV; OI15

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD