Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface recepto...[+]

Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors. Capable of inducing dorsal development in embryos. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA. None of these molecules causes dorsal mesoderm formation when expressed alone. [-]

             proximal symphalangism 1
             brachydactyly type B2
             multiple synostoses syndrome
             tarsal-carpal coalition syndrome
             proximal symphalangism

          TARSAL-CARPAL COALITION SYNDROME; TCC
          MULTIPLE SYNOSTOSES SYNDROME 1; SYNS1
          STAPES ANKYLOSIS WITH BROAD THUMBS AND TOES
          SYMPHALANGISM, PROXIMAL, 1A; SYM1A

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD

GSE64551, GSE83784, GSE112718.