Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10969734). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled protei...[+]

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10969734). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10969734). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). [-]

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