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Summary Expression Phenotypes Gene Literature (23) GO Terms (74) Nucleotides (67) Proteins (37) Interactants (207) Wiki
XB-GENEPAGE- 479706

Show:     All X. tropicalis X. laevis

Protein sequences for fzd5 - All


Models (23)

Source Version Model Species
NCBI 10.1 XBmRNA77211 X. laevis.L
NCBI 10.1 XBmRNA82251 X. laevis.S
NCBI 10.0 mRNA038589 X. tropicalis
ENSEMBL 10.0 ENSXETP00000115813 X. tropicalis
Xenbase 9.2 rna49245 X. laevis.L
Xenbase 9.2 rna11106 X. laevis.S
JGI 9.1 Xelaev18044974m X. laevis.L
Xenbase 9.1 rna40466 X. tropicalis
JGI 9.1 Xelaev18047383m X. laevis.S
JGI 8.0 Xetrov14037837m X. tropicalis
JGI 7.2 Xelaev16068549m X. laevis.S
JGI 7.1 Xetro.I00437.1 X. tropicalis
JGI 6.0 XeXenL6RMv10033694m X. laevis.S
JGI 6.0 XeXenL6RMv10053047m X. laevis.S
JGI 4.1 e_gw1.264.77.1 X. tropicalis
JGI 4.1 e_gw1.264.89.1 X. tropicalis
JGI 4.1 gw1.264.77.1 X. tropicalis
JGI 4.1 gw1.264.89.1 X. tropicalis
JGI 4.1 gw1.264.8.1 X. tropicalis
JGI 4.1 fgenesh1_pm.C_scaffold_264000005 X. tropicalis
JGI 4.1 e_gw1.264.8.1 X. tropicalis
JGI 4.1 fgenesh1_pg.C_scaffold_264000028 X. tropicalis
ENSEMBL 4.1 ENSXETP00000035762 X. tropicalis

UniProtKB Protein Function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

AI Protein Function : The fzd5 gene encodes a membrane-bound receptor protein localized to the cell membrane, which functions as a wnt ligand receptor involved in the canonical beta-catenin signaling pathway. It is expressed in tissues including the neural crest, otic vesicle, branchial arches, cement gland, and developing eye. Its function is associated with regulating pigment cell development and patterning within the neural crest lineage.

NCBI Proteins (14)

Accession Species Source
A0A803K619 X. tropicalis Uniprot
KAE8580168 X. tropicalis RefSeq
XP_004917802 X. tropicalis NCBI Protein
AAI69396 X. laevis.S NCBI Protein
AAI69398 X. laevis.S NCBI Protein
AAK51688 X. laevis.S NCBI Protein
NP_001079217 X. laevis.S RefSeq
OCT61360 X. laevis.S NCBI Protein
OCT63879 X. laevis.L NCBI Protein
XP_018091692 X. laevis.L NCBI Protein
XP_018091694 X. laevis.L NCBI Protein

UniProt Proteins (4)

Accession Species Source
A0A803K619 (InterPro) X. tropicalis Uniprot
B7ZPB7 (InterPro) X. laevis.S TrEMBL
P58421 (InterPro) X. laevis.S TrEMBL
A0A1L8EX74 (InterPro) X. laevis.L TrEMBL