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Summary Expression Expr. PhenotypesPheno. Gene Literature (41)Lit. (41) GO Terms (24)GO (24) Nucleotides (30)Nucl. (30) Proteins (18)Prot. (18) Interactants (473)Interact. (473) Wiki
XB-GENEPAGE- 478063

Show:     All X. tropicalis X. laevis

Protein sequences for foxh1.2 - All


Models (14)

Source Version Model Species
NCBI 10.1 XBmRNA53445 X. laevis.L
Xenbase 9.2 rna92311 X. laevis.L
JGI 9.1 Xelaev18032544m X. laevis.L
JGI 7.2 Xelaev16010674m X. laevis.L
JGI 7.1 Xetro.K04008.1 X. tropicalis
JGI 6.0 XeXenL6RMv10030744m X. laevis.L
JGI 4.1 gw1.1621.25.1 X. tropicalis
JGI 4.1 e_gw1.1621.24.1 X. tropicalis
JGI 4.1 gw1.1621.26.1 X. tropicalis
JGI 4.1 e_gw1.1621.25.1 X. tropicalis
JGI 4.1 e_gw1.1621.26.1 X. tropicalis
ENSEMBL 4.1 ENSXETP00000011563 X. tropicalis
JGI 4.1 fgenesh1_pg.C_scaffold_1621000003 X. tropicalis
JGI 4.1 gw1.1621.24.1 X. tropicalis

UniProtKB Protein Function: Transcriptional activator. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 2 (ARF2), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much higher affinity than foxh1/fast-1. Acts with foxh1/fast-1 to control the convergent extension movements of gastrulation.

AI Protein Function : foxh1.2 is a forkhead box transcription factor that acts as a co‑activator of Smad2/3 in the Nodal pathway. It functions as a nuclear transcriptional regulator required for mesoderm and endoderm induction. The protein localizes to the nucleus. Expression is detected in the dorsal marginal zone of early embryos, the marginal zone during gastrulation, the pre‑Spemann organizer, notochord progenitors, somites, pronephric tubules, neural plate, neural tube and tailbud. Loss‑of‑function disrupts convergent extension movements and impairs left‑right asymmetry.

NCBI Proteins (4)

Accession Species Source
CAD29460 X. laevis.L NCBI Protein
NP_001165546 X. laevis.L RefSeq
OCT77343 X. laevis.L NCBI Protein

UniProt Proteins (1)

Accession Species Source
Q8JIT7 (InterPro) X. laevis.L Swiss-Prot