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Fig. 5. Effect of retinoic acid (RA) on xCyp26c expression. (A-X)
Embryos were treated with various doses of RA at stage 8, cultured until stage 13, and then prepared for WISH analysis. No treatment (A-C). RA treatment (D-X). Concentration of RA (M) is shown on left side. Expres- sion pattern of xCyp26c (A-E), xCyp26a (I-P) and xOtx2 and xkrox20 (Q- X). Moderate doses of RA increased xCyp26c expression, but narrowed the area of expression (A-M). Over 10-6 M of RA, xCyp26c expression became restricted in the anterior neuroectoderm and underwent no further change (F-H). XCyp26a was expressed throughout the embryo (O,P), whereas xOtx2 expression completely disappeared (V-X). (Y) Real-time PCR analysis with whole embryos treated with RA. These graphs are expressed as ratio of expression level of RA-treated embryo (lane 2-7) to that of no-RA treated embryo (lane 1). |
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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
cyp26a1
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laevis
|
NF stage 24
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ventral blood island
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cyp26a1
|
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laevis
|
NF stage 28
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olfactory placode
,
otic vesicle
,
brain
,
forebrain
,
tail bud
,
[+]
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cyp26a1
|
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laevis
|
NF stage 35 and 36
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fin
,
otic vesicle
,
lens
,
pronephric duct
,
tail bud
,
[+]
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cyp26c1
|
|
laevis
|
NF stage 33 and 34
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otic vesicle
,
brain
,
hindbrain
,
visceral pouch
,
cranial nerve
,
[+]
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Fig. 3. Spatial expression of xCyp26c after tailbud stage. (A-B, D-E, G-H) XCyp26c expression. (C,F,I) XCyp26a expresion. Stage 24 (A-C), stage 28 (D-F), and stage 36 (G- I). XCyp26c was expressed in restricted sets of cranial nerves (GC(VII) and GC(IX)). XCyp26c was also expressed in the pharyngeal pouch (PP) and rhombomeric cells (r2/3 and r6). These patterns were obviously different from those of xCyp26a (C,F,I). |
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cyp26c1 ( cytochrome P450, family 26, subfamily C, polypeptide 1 ) gene expression in Xenopus laevis embryo, NF stage 24, as assayed by in situ hybridization, lateral view, anterior left, dorsal up. |