|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
twist1
|
|
tropicalis
|
NF stage 24
|
hyoid crest
,
neural crest
,
trunk neural crest
,
cranial neural crest
,
migratory neural crest cell
|
twist1
|
|
tropicalis
|
NF stage 28
|
neural crest
,
branchial arch
,
cranial neural crest
,
migratory neural crest cell
|
twist1
|
|
tropicalis
|
NF stage 14
|
neural crest
,
cranial neural crest
|
sox3
|
|
tropicalis
|
NF stage 14
|
pre-chordal neural plate
,
chordal neural plate
,
neural plate
|
gsc
|
|
tropicalis
|
NF stage 28
|
neural crest
,
branchial arch
,
cranial neural crest
|
snai2
|
|
tropicalis
|
NF stage 24
|
mandibular crest
,
hyoid crest
,
neural crest
,
cranial neural crest
,
migratory neural crest cell
|
sox9
|
|
tropicalis
|
NF stage 28
|
retina
,
mandibular crest
,
neural crest
,
eye
,
optic vesicle
,
[+]
|
krt12.4
|
|
tropicalis
|
NF stage 14
|
epidermis
|
|
|
Fig 3. Knockdown of nol11 disrupts cranial neural crest development.
At stages 14 and 24 neural and CNC development appears normal in one side treated embryos, as assayed by expression of key marker genes including sox3, cytokeratin, twist and slug. By stage 28 however, reductions are apparent in the expression of numerous CNC genes. The branchial arches are also smaller on the MO treated side at stage 28. Graph displays number of embryos exhibiting abnormal gene expression in control and nol11 morphant embryos.
doi:10.1371/journal.pgen.1005018.g003 |