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Fig. 3. The molecular identity of the hindbrain is determined by retinoid signalling mostly during gastrulation. Whole-mount in situ hybridizations on tadpole (st. 32) Xenopus laevis embryos. The upper row shows non-treated embryos; the middle row embryos treated with 10-6 M AGN from the blastula until the point of fixation; the lowest row embryos treated with 10-6 M AGN from st. 13 until the point of fixation. All views are lateral. (A) Hoxb-1, (B) Hoxd-3, (C) En2, Krox-20 and Hoxb-4, (D) Hoxa-5, (E) Krox-20 and Hoxc- 6. Arrows point to the anterior expression border of each Hox gene. |