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Figure 5 | Disassembly of the IrxA cluster alters the expression patterns
of IrxA genes. Genome architecture and expression patterns of IrxA genes
in ( a ) Xenopus , ( b ) medaka and ( c ) zebrafish. Expression patterns at
neurula stages are shown in lateral and dorsal (insets) views. In a , b ,
numbers in parentheses indicate the intergenic distances, and in c it
represents the size of orthologous IrxAa DNA associated with each gene.
Red arrowheads point at Irx4 expression in the heart. Coloured rectangles:
enhancers analysed in this study by 3C. Some of these enhancers, as well
as others, were lost upon disaggregation of zebrafish IrxAa cluster. Scale
bars, 0.5 mm. |
