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mnx1xenopus   

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Experiment details for mnx1

Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

Gene Clone Species Stages Anatomy
mnx1.L laevis NF stage 17 neuroectoderm , neural groove , neural plate , neural tube

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  Fig. 1. Expression of Nkx6 genes in X. laevis. (A–E) Whole mount in situ hybridization showing Nkx6.1 expression. (A) Nkx6.1 is not expressed during gastrulation. (B) Expression begins at stage 13 in two lateral stripes (red arrowhead) and intensifies at stage 14 (C). At stage 17 (D) Nkx6.1 expression marks where Hb9-positive MNs will form (compare to (M). (E) At stage 34, Nkx6.1 is expressed in the ventral spinal cord and hindbrain as well as the foregut (red arrowhead). (F–J) Whole mount in situ hybridization showing Nkx6.2 expression. (F) Nkx6.2 is expressed during gastrulation in the dorsal ectoderm. Red line indicates the dorsal blastopore lip. (G) At stage 13, Nkx6.2 expression is detected in a broad part of the medial neural plate. At stage 14 (H) and stage 17 (I) Nkx6.2 expression extends through the medial developing hindbrain and spinal neural plate. (J) At stage 34, Nkx6.2 expression is detected in the ventral spinal cord and hindbrain as well as the foregut (red arrowhead). Nkx6.1 and Nkx6.2 expression is confined to the medial part of the neural plate when compared to the pan-neural marker Sox2 expression (compare (C, H) to (K); and (D, I) to, (L)). (N,O) Neither Nkx6.1 (N; red arrowhead) nor Nkx6.2 (O; red arrowhead) expression overlaps with Dbx1 expression (N,O; black arrows) at stage 16.