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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
setd7	xenopus		neural tube [+] Mauthner cell,accessory olfactory bulb,adenohypophysis,amygdala,anterior amygdala,anterior commissure,anterior entopeduncular nucleus,anterior entopeduncular region,anterior hypothalamus,anterior tectum,anterior thalamic nucleus,anterodorsal tegmental nucleus,anteroventral tegmental nucleus,astrocyte,astrocyte end-foot,basal forebrain,basal ganglion,bed nucleus of the stria terminalis,brain ventricle,caudal tuberal region,cell body layer of the optic tectum,central amygdala,central nucleus of the thalamus,cerebellum,diencephalon,dorsal column nucleus,dorsal habenular nucleus,dorsal pallidum,dorsal pallium,dorsal septum,dorsal tegmentum,dorsal telencephalon,dorsal thalamus,eminentia thalami,external plexiform layer of the olfactory bulb,forebrain,forebrain-midbrain boundary,fourth ventricle,glomerular layer of the olfactory bulb,granule cell,granule cell layer of the cerebellum,granule cell layer of the olfactory bulb,habenula,hindbrain,hypophysis,hypothalamus,infundibulum,isthmic nucleus,lateral amygdala,lateral forebrain bundle,lateral ganglionic eminence,lateral hypothalamic nucleus,lateral pallium,lateral septum,laterodorsal tegmental nucleus,locus coeruleus,magnocellular preoptic nucleus,mammilary region,medial amygdala,medial ganglionic eminence,medial pallium,medial septum,medulla oblongata,melanotrope,mesencephalic artery,mesencephalic vein,metencephalic artery,metencephalic vein,midbrain,midbrain tegmentum,midbrain-hindbrain boundary,mitral cell,mitral cell layer of the olfactory bulb,neural stem cell,neurohypophysis,neuropil of the optic tectum,nucleus accumbens,nucleus of the diagonal band,nucleus of the solitary tract,nucleus reticularis inferior,nucleus reticularis medialis,nucleus reticularis superior,oculomotor motornucleus,olfactory bulb,oligodendrocyte,optic chiasm,optic stalk,optic tectum,optic tract,pallidum,pallium,pars distalis,pars intermedia,pars nervosa,pia mater,pial cell,pineal gland,posterior commissure,posterior hypothalamus,posterior tectum,posterodorsal tegmental nucleus,posteroventral tegmental nucleus,preoptic area,pretectum,prethalamus,prethalamus basal plate,prosomere,prosomere 4,prosomere 5,prosomere 6,radial glial cell,raphe nucleus,retromammillary area,rhombic lip,rhombomere,rostral tuberal region,solitary tract,stria terminalis,striatum,subcommissural organ,subpallium,subthalamic nucleus,suprachiasmatic nucleus,supraoptoparaventricular region,telencephalon,telencephalon septum,thalamus,third ventricle,torus semicircularis,trochlear motornucleus,tuberal region,ventral habenular nucleus,ventral hypothalamic nucleus,ventral pallidum,ventral pallium,ventral septum,ventral tegmentum,ventricular layer of the optic tectum,ventricular zone,ventrolateral thalamic nucleus,ventromedial thalamic nucleus,zona limitans intrathalamica,brain

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Experiment details for setd7

The histone methyltransferase Setd7 promotes pancreatic progenitor identity.

The histone methyltransferase Setd7 promotes pancreatic progenitor identity.

Gene	Clone	Species	Stages	Anatomy
setd7.L		laevis	NF stage 29 and 30	neural tube

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Fig. 1. Expression of Setd7 in the developing pancreas is conserved across vertebrate species. (A) RT-qPCR analysis of indicated transcription factors in anterior (AE) and posterior (PE) endodermal explants isolated from gastrula stage (st.) Xenopus embryos and cultured ex vivo until indicated stages. AE but not PE gives rise to pancreatic endoderm that expresses foxa2, pdx1 and ptf1a (Fig. S2) (Kelly and Melton, 2000; Horb and Slack, 2001; Spagnoli and Brivanlou, 2008). Data were normalized to that of odc and represented as fold change compared with PE sample (set to 1). n=4; error bars represent ±s.e.m. *P<0.05, **P<0.01. (B-E) In situ hybridization analysis of setd7 (B,E), pdx1 (C) and insulin (D) expression in cross-sectioned Xenopus tadpole (st. 30) embryos and dissected gut at st. 41 (E). Yellow star (*) indicates setd7 expression in the neural tube. dp, dorsal pancreatic bud; lv, liver bud; pa, pancreas. (F-J) Immunofluorescence analysis of Setd7 in the mouse endoderm and pancreas. Setd7 colocalizes with Foxa2 in the foregut endodermat E8.5 (8- to 9-somite stages) (F; dotted line demarcates the ventral foregut epithelium) and with Pdx1 in pancreatic progenitors at E10.5 (G). At E12.5 and 14.5 (H,H′,I), Setd7 is retained in the cytoplasm of pancreatic epithelium (arrowheads) and nuclear localization is detected only in delaminating cells (arrows). At E17.5 (J), Setd7 protein colocalizes with Pdx1 and insulin (Ins) in β-cell progenitors (arrows) clustering into islets. Arrowheads indicate Setd7 nuclear staining in neighbouring islet cells. Scale bars: 50 μm.