| |
Fig. 6. BMP inhibition prevents the intercalation of MCCs, ionocytes and SSCs in the outer layer of the developing Xenopus epidermis. (A-E′) Sectioning
through the epidermis at stage 25 revealed that in the BMP MO-injected embryos the supernumerary α-tubulin-positive MCCs (red in A-C′) and v1a-positive
ionocytes (red in D-E′) fail to intercalate into the epidermis outer layer. (I-J′) Likewise, the supernumerary tph1-positive SSCs failed to intercalate in stage 35 BMP
morphants (red in I-J′). (F-H′,K-M′) Even at later developmental stages, most of the supernumerary MCCs, which expressed the differentiation marker acetylated
tubulin (white), were unable to intercalate properly into the outer layer. |
