Dev Genet 1990 Jan 01;115-6:369-76. doi: 10.1002/dvg.1020110508.

Heterodimeric capping proteins constitute a highly conserved group of actin-binding proteins.

Abstract
The two subunits of the heterodimeric protein cap32/34, an actin-binding protein, are encoded by separate single-copy genes. We have established the genomic structure of both genes. A sequence comparison of cap32/34 with capZ from chicken skeletal muscle and two partially known sequences from Saccharomyces cerevisiae and Xenopus laevis show that heterodimeric capping proteins belong to a highly conserved group of actin-binding proteins. This conclusion is supported by the cross-reaction of polyclonal antibodies against cap32 and cap34 with proteins from lower and higher eukaryotes. In addition, a system is presented that allows the expression of truncated cap34 polypeptides under the control of the cap34 promoter.

PubMed ID: 1710551
Article link: Dev Genet


Species referenced: Xenopus laevis
Genes referenced: actl6a capza1