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XB-ART-30001
Dev Biol 1983 Nov 21;2791-2:303-7.
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Cyclic AMP reduction of frequency following ability in peripheral axons.

Seelig TL , Grossman Y , Kendig JJ .


Abstract
Radioimmunoassays for cAMP demonstrated that a beta-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.

PubMed ID: 6196092
Article link: Dev Biol
Grant support: [+]

Genes referenced: camp