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Proc Natl Acad Sci U S A
2000 Dec 19;9726:14358-63. doi: 10.1073/pnas.250492197.
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Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation.
Tian J
,
Kim S
,
Heilig E
,
Ruderman JV
.
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Quiescent full-grown Xenopus oocytes remain arrested at the G(2)/M border of meiosis I until exposed to progesterone, their natural mitogen. Progesterone triggers rapid, nontranscriptional responses that lead to the translational activation of stored mRNAs, resumption of the meiotic cell cycles, and maturation of the oocyte into a fertilizable egg. It has long been presumed that progesterone activates the oocyte through a novel nontranscriptional signaling receptor. Here, we provide evidence that a conventional transcriptional progesterone receptor cloned from Xenopus oocytes, XPR-1, is required for oocyte activation. Overexpression of XPR-1 through mRNA injection increases sensitivity to progesterone and accelerates progesterone-activated cell cycle reentry. Injection of XPR-1 antisense oligonucleotides blocks the ability of oocytes to respond to progesterone; these oocytes are rescued by subsequent injection of XPR-1 or the human progesterone receptor PR-B. Antisense-treated oocytes can be activated in response to inhibition of protein kinase A, one of the earliest known changes occurring downstream of progesterone stimulation. These results argue that the conventional progesterone receptor also functions as the signaling receptor that is responsible for the rapid nontranscriptional activation of frog oocytes.
Akamatsu,
Transcription factor E2F and cyclin E-Cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes.
1998, Pubmed,
Xenbase
Akamatsu,
Transcription factor E2F and cyclin E-Cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Andrésson,
The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway.
1998,
Pubmed
,
Xenbase
Bandyopadhyay,
Plasma membrane mediated action of progesterone in amphibian (Rana dybowskii) oocyte maturation.
1998,
Pubmed
Castoria,
Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.
1999,
Pubmed
Chen,
Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen.
1999,
Pubmed
Clarke,
Perimembrane localization of the estrogen receptor alpha protein in neuronal processes of cultured hippocampal neurons.
2000,
Pubmed
Cork,
Second messenger signalling during hormone-induced Xenopus oocyte maturation.
1994,
Pubmed
,
Xenbase
Ferrell,
Xenopus oocyte maturation: new lessons from a good egg.
1999,
Pubmed
,
Xenbase
Finidori-Lepicard,
Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes.
1981,
Pubmed
,
Xenbase
Fortune,
Ovarian progesterone levels during in vitro oocyte maturation and ovulation in Xenopus laevis.
1975,
Pubmed
,
Xenbase
Godeau,
Induction of maturation in Xenopus laevis oocytes by a steroid linked to a polymer.
1978,
Pubmed
,
Xenbase
Horwitz,
In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation.
1983,
Pubmed
Ishikawa,
Primary action of steroid hormone at the surface of amphibian oocyte in the induction of germinal vesicle breakdown.
1977,
Pubmed
,
Xenbase
Iwashita,
Essential role of germinal vesicle material in the meiotic cell cycle of Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Kastner,
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
1990,
Pubmed
Maller,
Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase.
1977,
Pubmed
,
Xenbase
Maller,
Regulation of amphibian oocyte maturation.
1985,
Pubmed
,
Xenbase
Maller,
Recurring themes in oocyte maturation.
1998,
Pubmed
Maller,
The elusive progesterone receptor in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Masui,
Relative roles of the pituitary, follicle cells, and progesterone in the induction of oocyte maturation in Rana pipiens.
1967,
Pubmed
Masui,
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
1971,
Pubmed
McEwan,
Gene regulation through chromatin remodelling by members of the nuclear receptor superfamily.
2000,
Pubmed
McKenna,
Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.
1999,
Pubmed
Mendez,
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.
2000,
Pubmed
,
Xenbase
Migliaccio,
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor.
1998,
Pubmed
Migliaccio,
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.
1993,
Pubmed
Migliaccio,
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.
1996,
Pubmed
Morrill,
Progesterone binding to plasma membrane and cytosol receptors in the amphibian oocyte.
1997,
Pubmed
Morrill,
Progesterone induces meiotic division in the amphibian oocyte by releasing lipid second messengers from the plasma membrane.
1999,
Pubmed
Morrison,
Nongenomic action of progesterone: activation of Xenopus oocyte phospholipase C through a plasma membrane-associated tyrosine kinase.
2000,
Pubmed
,
Xenbase
Murakami,
Mechanisms of Xenopus oocyte maturation.
1997,
Pubmed
,
Xenbase
Nagahama,
17 alpha,20 beta-dihydroxy-4-pregnen-3-one, a maturation-inducing hormone in fish oocytes: mechanisms of synthesis and action.
1997,
Pubmed
Palmer,
The activation of MAP kinase and p34cdc2/cyclin B during the meiotic maturation of Xenopus oocytes.
2000,
Pubmed
,
Xenbase
Razandi,
Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.
1999,
Pubmed
Revelli,
Nongenomic actions of steroid hormones in reproductive tissues.
1998,
Pubmed
Russell,
Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling.
2000,
Pubmed
Sadler,
Progesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein.
1981,
Pubmed
,
Xenbase
Sagata,
What does Mos do in oocytes and somatic cells?
1997,
Pubmed
,
Xenbase
Schuetz,
Action of hormones on germinal vesicle breakdown in frog (Rana pipiens) oocytes.
1967,
Pubmed
Smith,
In vitro induction of physiological maturation in Rana pipiens oocytes removed from their ovarian follicles.
1968,
Pubmed
Smith,
Role of the oocyte nucleus in physiological maturation in Rana pipiens.
1969,
Pubmed
Smith,
The interaction of steroids with Rana pipiens Oocytes in the induction of maturation.
1971,
Pubmed
Takimoto,
Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors.
1996,
Pubmed
Wallace,
Protein incorporation by isolated amphibian oocytes. 3. Optimum incubation conditions.
1973,
Pubmed
,
Xenbase
Wasserman,
A study on gonadotropin action in the induction of oocyte maturation in Xenopus laevis.
1974,
Pubmed
,
Xenbase
Weatherman,
Nuclear-receptor ligands and ligand-binding domains.
1999,
Pubmed
Wehling,
Specific, nongenomic actions of steroid hormones.
1997,
Pubmed
Xu,
Coactivator and corepressor complexes in nuclear receptor function.
1999,
Pubmed
Yamashita,
Molecular mechanisms of the initiation of oocyte maturation: general and species-specific aspects.
2000,
Pubmed
