XB-ART-44606
Dev Cell
2011 Sep 13;213:410-9. doi: 10.1016/j.devcel.2011.07.018.
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And the dead shall rise: actin and myosin return to the spindle.
Sandquist JC
,
Kita AM
,
Bement WM
.
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The spindle directs chromosome partitioning in eukaryotes and, for the last three decades, has been considered primarily a structure based on microtubules, microtubule motors, and other microtubule binding proteins. However, a surprisingly large body of both old and new studies suggests roles for actin filaments (F-actin) and myosins (F-actin-based motor proteins) in spindle assembly and function. Here we review these data and conclude that in several cases the evidence for the participation of F-actin and myosins in spindle function is very strong, and in the situations where it is less strong, there is nevertheless enough evidence to warrant further investigation.
???displayArticle.pubmedLink??? 21920311
???displayArticle.pmcLink??? PMC3197778
???displayArticle.link??? Dev Cell
???displayArticle.grants??? [+]
5F32GM090674 NIGMS NIH HHS , GM052932 NIGMS NIH HHS , F32 GM090674-02 NIGMS NIH HHS , R01 GM052932-14 NIGMS NIH HHS , R01 GM052932 NIGMS NIH HHS , F32 GM090674 NIGMS NIH HHS
Species referenced: Xenopus
Genes referenced: actl6a
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