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Mol Endocrinol
2008 May 01;225:1065-77. doi: 10.1210/me.2007-0492.
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Participation of Brahma-related gene 1 (BRG1)-associated factor 57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development.
Heimeier RA
,
Hsia VS
.
Abstract
Multiple cofactors and chromatin remodeling complexes have been identified to contribute to the transcriptional activation regulated by thyroid hormone receptors (TRs) in vitro. However, their role and function during development in vivo remains to be elucidated. The total dependence of amphibian metamorphosis on thyroid hormone T3 provides a unique vertebrate model for studying the molecular mechanism of TR function in vivo. In this study, we show that the expression of Brahma-related gene 1 (BRG1), a chromatin-remodeling enzyme, is up-regulated at the climax of Xenopus laevis metamorphosis, whereas BRG1-associated factor 57 (BAF57), a BRG1-binding protein in BRG1-containing chromatin remodeling complexes, is constitutively expressed during development. Consistently, T3 treatment of premetamorphic tadpoles led to up-regulation of the expression of BRG1 but not BAF57. Studies using a reconstituted T3-dependent Xenopus oocyte transcription system, where we could study TR function in the context of chromatin, revealed that BRG1 enhances the transcriptional activation by ligand-bound TRs in a dose-dependent manner, whereas a remodeling-defective BRG1 mutant inhibited the activation, suggesting that this process relies on chromatin remodeling. Additional studies showed that BAF57 interacted with BRG1 in oocytes and enhanced gene activation by TR cooperatively with BRG1 in vivo. Chromatin immunoprecipitation revealed that BAF57 was recruited to the TR-regulated promoter in the presence of TR and T3. Together, these findings suggest a role of BRG1/BAF57-containing chromatin remodeling complexes in TR-regulated gene expression during postembryonic development.
Amano,
Thyroid hormone regulation of a transcriptional coactivator in Xenopus laevis: implication for a role in postembryonic tissue remodeling.
2002, Pubmed,
Xenbase
Amano,
Thyroid hormone regulation of a transcriptional coactivator in Xenopus laevis: implication for a role in postembryonic tissue remodeling.
2002,
Pubmed
,
Xenbase
Amano,
Isolation of genes involved in intestinal remodeling during anuran metamorphosis.
1998,
Pubmed
,
Xenbase
Badenhorst,
Biological functions of the ISWI chromatin remodeling complex NURF.
2002,
Pubmed
Becker,
ATP-dependent nucleosome remodeling.
2002,
Pubmed
Belandia,
Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes.
2002,
Pubmed
Buchholz,
Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.
2006,
Pubmed
,
Xenbase
Buchholz,
Pairing morphology with gene expression in thyroid hormone-induced intestinal remodeling and identification of a core set of TH-induced genes across tadpole tissues.
2007,
Pubmed
,
Xenbase
Buchholz,
A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.
2003,
Pubmed
,
Xenbase
Buchholz,
Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.
2004,
Pubmed
,
Xenbase
Bultman,
A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.
2000,
Pubmed
Burke,
Co-repressors 2000.
2000,
Pubmed
Chen,
Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.
2005,
Pubmed
Cheng,
Thyroid hormone receptor mutations in cancer.
2003,
Pubmed
Chi,
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
2002,
Pubmed
Côté,
Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding.
1998,
Pubmed
Das,
Gene expression changes at metamorphosis induced by thyroid hormone in Xenopus laevis tadpoles.
2006,
Pubmed
,
Xenbase
Decristofaro,
Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies.
2001,
Pubmed
Denver,
Thyroid hormone-dependent gene expression program for Xenopus neural development.
1997,
Pubmed
,
Xenbase
Dilworth,
ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro.
2000,
Pubmed
Domingos,
Cloning and developmental expression of Baf57 in Xenopus laevis.
2002,
Pubmed
,
Xenbase
Evans,
The steroid and thyroid hormone receptor superfamily.
1988,
Pubmed
Flamant,
Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.
2003,
Pubmed
Fondell,
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
1993,
Pubmed
Fryer,
Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.
1998,
Pubmed
García-Pedrero,
The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells.
2006,
Pubmed
Gelius,
Characterization of a chromatin remodelling activity in Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Hassan,
Promoter targeting of chromatin-modifying complexes.
2001,
Pubmed
Hsia,
Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor.
2002,
Pubmed
,
Xenbase
Hsiao,
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.
2003,
Pubmed
Huang,
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription.
2003,
Pubmed
,
Xenbase
Ito,
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function.
2001,
Pubmed
Jepsen,
Biological roles and mechanistic actions of co-repressor complexes.
2002,
Pubmed
Jones,
N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors.
2003,
Pubmed
,
Xenbase
Kadam,
Mechanisms of chromatin assembly and transcription.
2002,
Pubmed
Kiskinis,
Identification of BAF57 mutations in human breast cancer cell lines.
2006,
Pubmed
Lazar,
Thyroid hormone receptors: multiple forms, multiple possibilities.
1993,
Pubmed
Lemon,
Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.
,
Pubmed
Li,
The role of chromatin during transcription.
2007,
Pubmed
Link,
BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF.
2005,
Pubmed
Mangelsdorf,
The nuclear receptor superfamily: the second decade.
1995,
Pubmed
Martens,
Recent advances in understanding chromatin remodeling by Swi/Snf complexes.
2003,
Pubmed
Matsumoto,
Brg1 is required for murine neural stem cell maintenance and gliogenesis.
2006,
Pubmed
McKenna,
Nuclear receptors, coregulators, ligands, and selective receptor modulators: making sense of the patchwork quilt.
2001,
Pubmed
Muchardt,
A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.
1993,
Pubmed
Muchardt,
ATP-dependent chromatin remodelling: SWI/SNF and Co. are on the job.
1999,
Pubmed
Muchardt,
When the SWI/SNF complex remodels...the cell cycle.
2001,
Pubmed
Müller,
Chromatin remodeling in development and differentiation.
2001,
Pubmed
Neigeborn,
Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae.
1984,
Pubmed
Nie,
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex.
2000,
Pubmed
Oppenheimer,
Advances in our understanding of thyroid hormone action at the cellular level.
1987,
Pubmed
Ostlund Farrants,
Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex.
1997,
Pubmed
Pal,
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
2003,
Pubmed
Rachez,
Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.
2000,
Pubmed
Rachez,
Mediator complexes and transcription.
2001,
Pubmed
Samuels,
Regulation of gene expression by thyroid hormone.
1988,
Pubmed
Schreiber,
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
2001,
Pubmed
,
Xenbase
Seo,
Geminin regulates neuronal differentiation by antagonizing Brg1 activity.
2005,
Pubmed
,
Xenbase
Seo,
The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.
2005,
Pubmed
,
Xenbase
Shen,
Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates.
2003,
Pubmed
Shi,
Cloning and characterization of the ribosomal protein L8 gene from Xenopus laevis.
1994,
Pubmed
,
Xenbase
Stern,
Five SWI genes are required for expression of the HO gene in yeast.
1984,
Pubmed
Sumi-Ichinose,
SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells.
1997,
Pubmed
Tamkun,
The role of brahma and related proteins in transcription and development.
1995,
Pubmed
Tomita,
Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development.
2004,
Pubmed
,
Xenbase
Tomita,
Fusion protein of retinoic acid receptor alpha with promyelocytic leukemia protein or promyelocytic leukemia zinc finger protein recruits N-CoR-TBLR1 corepressor complex to repress transcription in vivo.
2003,
Pubmed
,
Xenbase
Tsai,
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
1994,
Pubmed
Versteege,
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.
1998,
Pubmed
Vignali,
ATP-dependent chromatin-remodeling complexes.
2000,
Pubmed
Wallberg,
Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain.
2000,
Pubmed
Wang,
BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.
2004,
Pubmed
Wang,
Diversity and specialization of mammalian SWI/SNF complexes.
1996,
Pubmed
Wang,
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.
1996,
Pubmed
Wang,
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.
1998,
Pubmed
Wolffe,
Three steps in the regulation of transcription by the thyroid hormone receptor: establishment of a repressive chromatin structure, disruption of chromatin and transcriptional activation.
1997,
Pubmed
,
Xenbase
Wolffe,
Chromatin remodeling regulated by steroid and nuclear receptors.
1997,
Pubmed
Wong,
Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors.
1995,
Pubmed
,
Xenbase
Wong,
A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.
1995,
Pubmed
,
Xenbase
Workman,
Alteration of nucleosome structure as a mechanism of transcriptional regulation.
1998,
Pubmed
Yen,
Physiological and molecular basis of thyroid hormone action.
2001,
Pubmed
Yoshinaga,
Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors.
1992,
Pubmed
Yoshizato,
Biochemistry and cell biology of amphibian metamorphosis with a special emphasis on the mechanism of removal of larval organs.
1989,
Pubmed
Zhang,
The mechanism of action of thyroid hormones.
2000,
Pubmed
