Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
The problem of automation in animal development: confrontation of the concept of cell sociology with biochemical data.
Chandebois R
.
Abstract
The principles of automation in animal development, as previously inferred from the concept of Cell Sociology do not fit in well with the current concept of sequential genet derepression. A more adequate explanation for those principles has been found in the literature dealing with the biochemical aspects of differentiation. Since oocytes and embryonic cells contain a greater variety of mRNAs than differentiated cells, as well as many tissue-specific (luxury) substances, it is concluded that the diversification of tissues consists of a progressive selection of specific metabolic strategies, mediated by cell-to-cell contacts, from a broad range of pre-existing strategies. For each tissue, prior to its final determination, one luxury metabolic strategy is progressively intensified and becomes dominant. The others are either suppressed or maintained as latent metabolic strategies. The latter may on occasion become dominant again (transdifferentiation). These phenomena require a theory which considers gene regulation as the activation of otherwise repressed genes by specific activator RNAs. The high (apparently maximal) transcriptional activity on the lampbrush chromosomes may represent the synthesis of all the kinds of activator RNAs which are required for the reactivation of the genes during early development. A general conception is propounded of the automatism and programming of animal development, as inferred from the confrontation of these ideas with the concept of Cell Sociology.
Affara,
Regulation of a group of abundant mRNA sequences during Friend cell differentiation.
1979, Pubmed
Affara,
Regulation of a group of abundant mRNA sequences during Friend cell differentiation.
1979,
Pubmed
Anthony,
Initiation by the DNA-dependent RNA polymerase.
1966,
Pubmed
Brandhorst,
Two-dimensional gel patterns of protein synthesis before and after fertilization of sea urchin eggs.
1976,
Pubmed
Britten,
Gene regulation for higher cells: a theory.
1969,
Pubmed
CLEVER,
[Gene activity in the giant chromosomes of Chironomus tentans and its relation to development. I. Gene activation by ecdysone].
1961,
Pubmed
Chandebois,
Cell sociology: a way of reconsidering the current concepts of morphogenesis.
1976,
Pubmed
Chandebois,
Cell sociology and the problem of position effect: pattern formation, origin and role of gradients.
1977,
Pubmed
Chandebois,
Cell sociology and the problem of automation in the development of pluricellular animals.
1980,
Pubmed
Church,
Ribonucleic acid synthesis in regenerating and embryonic liver. II. The synthesis of RNA during embryonic liver development and its relationship to regenerating liver.
1967,
Pubmed
Clayton,
Relationship between crystallin mRNA expression in retina cells and their capacity to re-differentiate into lens cells.
1979,
Pubmed
Deshpande,
A reexamination of heart muscle differentiation in the postnodal piece of chick blastoderm mediated by exogenous RNA.
1977,
Pubmed
Deshpande,
A novel RNA affecting embryonic gene functions in early chick glastoderm.
1977,
Pubmed
Dym,
Sub-cellular distribution of the cytoplasmic myosin heavy chain mRNA during myogenesis.
1979,
Pubmed
Ebert,
An Analysis of the Synthesis and Distribution of the Contractile Protein, Myosin, in the Development of the Heart.
1953,
Pubmed
Eguchi,
Differentiation of lens-like structures from newt iris epithelial cells in vitro.
1974,
Pubmed
Eguchi,
Elicitation of lens formation from the "ventral iris" epithelium of the newt by a carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine.
1973,
Pubmed
Ellison,
Chondrogenesis in chick embryo somites in vitro.
1969,
Pubmed
FLICKINGER,
Localization of lens antigens in developing frog embryos.
1960,
Pubmed
FLICKINGER,
Sequential gene action, protein synthesis, and cellular differentiation.
1962,
Pubmed
Flickinger,
Effect of rate of replication upon transcription in chick embryo limb bud mesenchyme cells in organ culture.
1976,
Pubmed
Flickinger,
The effect of growth rate on differentiation of chick embryo limb bud mesenchyme in organ culture.
1976,
Pubmed
Franco-Browder,
THE IDENTIFICATION OF A SULFATED MUCOPOLYSACCHARIDE IN CHICK EMBRYOS, STAGES 11-23.
1963,
Pubmed
Gefter,
DNA replication.
1975,
Pubmed
Georgiev,
The structure of transcriptional units in eukaryotic cells.
1972,
Pubmed
Jazdowska-Zagrodzińska,
Experimental studies on the role of 'polar granules' in the segregation of pole cells in Drosophila melanogaster.
1966,
Pubmed
Kanehisa,
Partial specificity of low-molecular weight RNA that stimulates RNA synthesis in various tissues.
1974,
Pubmed
Karkinen-Jääskeläinen,
Permissive and directive interactions in lens induction.
1978,
Pubmed
Kronenberg,
Double-stranded ribonucleic acid in sea urchin embryos.
1972,
Pubmed
Lash,
Differential behavior of anterior and posterior embryonic chick somites in vitro.
1967,
Pubmed
Lundquist,
Polar granules and pole cells in the embryo of Calliphora erythrocephala: ultrastructure and [3H]leucine labelling.
1980,
Pubmed
Mayfield,
Tissue differences in rat chromosomal RNA.
1971,
Pubmed
Mayfield,
A partial sequence of nuclear events in regenerating rat liver (gene regulation-chromosomal RNA).
1972,
Pubmed
McDonald,
External potassium and baby hamster kidney cells: intracellular ions, ATP, growth, DNA synthesis and membrane potential.
1972,
Pubmed
Medoff,
Enzymatic events during cartilage differentiation in the chick embryonic limb bud.
1967,
Pubmed
Monk,
A stem-line model for cellular and chromosomal differentiation in early mouse-development.
1981,
Pubmed
Niu,
The development of tubular heart in RNA-treated post-nodal pieces of chick blastoderm.
1973,
Pubmed
Noda,
An ultrastructural observation of Pelmatohydra robusta at sexual and asexual stages, with a special reference to "germinal plasm".
1977,
Pubmed
Okada,
Possible demonstration of multipotential nature of embryonic neural retina by clonal cell culture.
1979,
Pubmed
Orkin,
SDS gel analysis of muscle proteins in embryonic cells.
1973,
Pubmed
Perlman,
Prescence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis.
1977,
Pubmed
,
Xenbase
Pollard,
Actin and myosin and cell movement.
1974,
Pubmed
Pritchard,
'Transdifferentiation' of chicken neural retina into lens and pigment epithelium in culture: controlling influences.
1978,
Pubmed
SEARLS,
ISOLATION OF MUCOPOLYSACCHARIDE FROM THE PRECARTILAGINOUS EMBRYONIC CHICK LIMB BUD.
1965,
Pubmed
Stephens,
Extracellular matrix synthesis in the chick embryo lateral plate prior to and during limb outgrowth.
1980,
Pubmed
Sturgess,
Actin synthesis during the early development of Xenopus laevis.
1980,
Pubmed
,
Xenbase
Thomson,
Lens-specific mRNA in cultures of embryonic chick neural retina and pigmented epithelium.
1979,
Pubmed
Tsai,
Effect of estrogen on ovalbumin gene expression in differentiated nontarget tissues.
1979,
Pubmed
WILT,
The ontogeny of chick embryo hemoglobin.
1962,
Pubmed
Zagris,
Hemoglobins in single chick erythrocytes as determined by a differential elution procedure.
1978,
Pubmed
Zagris,
Erythroid cell differentiation in unincubated chick blastoderm in culture.
1980,
Pubmed
