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XB-ART-27697
Eur J Pharmacol 1988 Jan 19;1453:341-3. doi: 10.1016/0014-2999(88)90439-6.
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The neurotensin analog xenopsin excites nigral dopamine neurons.

Pozza MF , Küng E , Bischoff S , Olpe HR .


Abstract
The electrophysiological effects of neurotensin (NT), its analog xenopsin, and the fragment NT-(1-8) on the activity of dopaminergic neurons in rat substantia nigra slices were compared. Xenopsin and NT produced a concentration-dependent increase in the firing rate. The mean firing rate was increased by 58.5% with xenopsin (0.1 microM) and 49.1% with NT (0.1 microM). NT-(1-8) was inactive at this concentration. Dopamine (100 microM) inhibited firing in these neurons by 54.7%. These data provide evidence that xenopsin mimics the physiological effects of NT.

PubMed ID: 3350051
Article link: Eur J Pharmacol


Species referenced: Xenopus
Genes referenced: levi