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XB-ART-25023
Mol Cell Biol 1991 Mar 01;113:1713-7. doi: 10.1128/mcb.11.3.1713-1717.1991.
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Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe.

Freeman RS , Ballantyne SM , Donoghue DJ .


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We have investigated the relationship between Xenopus laevis c-mos (mosXe) and the cyclin B component of maturation-promoting factor. Microinjection of Xenopus oocytes with in vitro-synthesized RNAs encoding Xenopus cyclin B1 or cyclin B2 induces the progression of meiosis, characterized by germinal vesicle breakdown (GVBD). By preinjecting oocytes with a mosXe-specific antisense oligonucleotide, we show that GVBD induced by cyclin B does not require expression of the mosXe protein. GVBD induced by cyclin B proceeds significantly faster than GVBD induced by progesterone or MosXe. However, coinjection of RNAs encoding cyclin B1 or cyclin B2 with mosXe RNA results in a 2.5- to 3-fold acceleration in GVBD relative to that induced by cyclin B alone. This acceleration of GVBD does not correlate with changes in the level of cyclin B1 and cyclin B2 phosphorylation.

???displayArticle.pubmedLink??? 1825350
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Species referenced: Xenopus laevis
Genes referenced: ccnb1 ccnb1.2 ccnb2 cdk1 mos

References [+] :
Cyert, Regulation of MPF activity in vitro. 1988, Pubmed, Xenbase