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Development 1988 Dec 01;1044:631-41.
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Localization of c-myc expression during oogenesis and embryonic development in Xenopus laevis.

Hourdry J , Brulfert A , Gusse M , Schoevaert D , Taylor MV , Mechali M .

The expression of the proto-oncogene c-myc during oogenesis and embryonic development was followed by in situ hybridization using a cytological protocol adapted to amphibian embryos. The c-myc RNA was highly expressed in the cytoplasm of young oocytes and was further diluted during oocyte growth without specific localization. From the neurula stage on, new myc transcripts were detected and the whole embryo appeared positive with antisense myc RNA probes relative to control sense RNA probes. In addition, a spatial localization of high levels of the transcript was also observed in specific areas of the developing embryo, including the epidermis, gill buds, optic vesicles and lens placodes. These observations might indicate a specific role of the c-myc gene during the differentiation of these tissues. Alternatively, this high level of myc expression might prevent such tissues from entering into terminal differentiation during the growth of the embryo.

PubMed ID: 3077353

Species referenced: Xenopus laevis
Genes referenced: myc tbx2

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