Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-4764
Trends Neurosci 2003 Sep 01;269:453-5. doi: 10.1016/S0166-2236(03)00212-1.
Show Gene links Show Anatomy links

Dishevelled: linking convergent extension with neural tube closure.

Copp AJ , Greene ND , Murdoch JN .


???displayArticle.abstract???
Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.

???displayArticle.pubmedLink??? 12948650
???displayArticle.link??? Trends Neurosci


Species referenced: Xenopus
Genes referenced: dvl2