Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy.
Xiao H
,
Wang M
,
Du Y
,
Yuan J
,
Zhao G
,
Tu D
,
Liao YH
.
???displayArticle.abstract???
The calcium channel may be an important target in the autoimmune pathogenesis of dilated cardiomyopathy (DCM). The presence and function of serum autoantibodies against calcium channels (CC-AAbs) in patients with DCM were studied. Calcium-channel AAbs were detected in 80 patients with DCM and 80 controls by enzyme-linked immunosorbent assay (ELISA). Calcium-channel AAbs were further purified by affinity chromatography for characterization by immunoblotting and immunofluorescence. Voltage-clamp experiments were performed to identify the function of CC-AAbs. The presence of CC-AAbs was shown effectively by ELISA, and CC-AAbs were able specifically to bind to the calcium channel on the myocyte, confirmed by immunoblotting and immunofluorescence. Calcium currents were enhanced by CC-AAbs on Xenopus oocytes expressing human Ca(V)1.2 channels, which suggested CC-AAbs in patients with DCM were agonist-like. Our results suggest there are novel agonist-like CC-AAbs in patients with DCM. Calcium-channel AAbs might play an important role in the pathogenesis of DCM.
Bienertová-Vasků,
Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population.
2009, Pubmed
Bienertová-Vasků,
Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population.
2009,
Pubmed
Bourinet,
Dissecting the functional role of different isoforms of the L-type Ca2+ channel.
2004,
Pubmed
Catterall,
International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.
2003,
Pubmed
Dong,
Verapamil ameliorates the clinical and pathological course of murine myocarditis.
1992,
Pubmed
Felker,
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy.
2000,
Pubmed
Figulla,
Diltiazem improves cardiac function and exercise capacity in patients with idiopathic dilated cardiomyopathy. Results of the Diltiazem in Dilated Cardiomyopathy Trial.
1996,
Pubmed
Jahns,
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy.
2004,
Pubmed
Jane-wit,
Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis.
2007,
Pubmed
Kurt,
Short-term effect of levosimendan on free light chain kappa and lambda levels in patients with decompensated chronic heart failure.
2010,
Pubmed
Lei,
Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking.
2004,
Pubmed
Li,
An outwardly rectifying anionic background current in atrial myocytes from the human heart.
2007,
Pubmed
Liao,
Cardiac cytotoxic mechanism mediated by antibodies against myocardial mitochondrial ADP/ATP carrier in patients with dilated cardiomyopathy.
1996,
Pubmed
Liao,
Autoantibodies against ADP/ATP carrier from patients with dilated cardiomyopathy increase activity of voltage-dependent Ca channels in isolated cardiac myocytes.
1996,
Pubmed
Liao,
Infectious tolerance to ADP/ATP carrier peptides induced by anti-L3T4 monoclonal antibody in dilated cardiomyopathy mice.
2005,
Pubmed
Liao,
Autoimmunity in the pathogenesis of cardiomyopathy.
2001,
Pubmed
Liao,
Functional analysis of autoantibodies against ADP/ATP carrier from dilated cardiomyopathy.
1996,
Pubmed
Liao,
Interventional study of diltiazem in dilated cardiomyopathy: a report of multiple centre clinical trial in China. Chinese Cooperative Group of Diltiazem Intervention Trial in Dilated Cardiomyopathy.
1998,
Pubmed
MacLellan,
Dilated cardiomyopathy: learning to live with yourself.
2003,
Pubmed
Merrifield,
Solid-phase peptide synthesis.
1969,
Pubmed
Mobini,
Hemodynamic improvement and removal of autoantibodies against beta1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy.
2003,
Pubmed
Nishiyama,
Efficacy and safety of carvedilol for heart failure in children and patients with congenital heart disease.
2009,
Pubmed
Okazaki,
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.
2005,
Pubmed
Okazaki,
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.
2003,
Pubmed
Otsuka,
Enhanced expression of the ubiquitin-proteasome system in the myocardium from patients with dilated cardiomyopathy referred for left ventriculoplasty: an immunohistochemical study with special reference to oxidative stress.
2010,
Pubmed
Reichlin,
Cellular dysfunction induced by penetration of autoantibodies into living cells: cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins.
1998,
Pubmed
Richardson,
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies.
1996,
Pubmed
Schultheiss,
Antibody-mediated enhancement of calcium permeability in cardiac myocytes.
1988,
Pubmed
Schulze,
Impairment of myocardial calcium homeostasis by antibodies against the adenine nucleotide translocator.
1999,
Pubmed
Splawski,
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.
2005,
Pubmed
,
Xenbase
Sun,
The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone.
2010,
Pubmed
Takahashi,
Gender difference in arrhythmic occurrences in patients with nonischemic dilated cardiomyopathy and implantable cardioverter-defibrillator.
2010,
Pubmed
Wang,
Blockade action of ketanserin and increasing effect of potassium ion on Kv1.3 channels expressed in Xenopus oocytes.
2007,
Pubmed
,
Xenbase
Yoshikawa,
Autoimmune mechanisms underlying dilated cardiomyopathy.
2009,
Pubmed
Zhou,
Cardiac remodeling after long-term stimulation by antibodies against the alpha1-adrenergic receptor in rats.
2005,
Pubmed
